Weight Loss
Expected Weight Loss Timeline
After 4 weeks: Some weight loss is typically seen within the first 4 weeks of starting semaglutide, but the amount can vary widely between individuals. The STEP 1 trial reported an average weight loss of 3.8% after 4 weeks onthe 2.4 mg semaglutide dose.
After 12 weeks: At the 3-month mark in the STEP 1 trial, participants on semaglutide 2.4mg had lost an average of 9.6% of their baseline body weight, compared to 2.8% with placebo. After 6 months: In the same STEP 1 trial at 6 months, those on semaglutide 2.4mg had lost an average of 13.8% of their initial weight versus 3.7% with placebo.
After 12 months: Individuals can expect to lose approximately 15 to 17% of their baseline body weight on average after one year of treatment with the 2.4mg once-weekly semaglutide injection when combined with lifestyle interventions. Of course, the weight loss
response is variable, with some losing more than 20% and others experiencing a more modest 5 to 10% reduction.
When weight loss may plateau: For most people, the weight loss achieved with semaglutide starts to plateau around 9 to 12 months of treatment if the individual adheres to the medication and lifestyle recommendations. The overall weight loss sustained at 1 to 2 years is often 10 to 15% in responders.
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